In the 60's, there was the legendary sitcom, My Mother The Car, a fantasy-com that lasted just one season. Its premise suggested some sort of bizarre form of reincarnation or some such contrivance. However, viewers were made to assume that a talking car wasn't going to be a hit.
In 1982, producer Glen Larsen decided to test that theory with Knight Rider, which would end up being, I believe, his last series for Universal, as Larsen moved his tack to 20th Century Fox the following year.
Knight Rider told the story of a police officer, Michael Long (David Hasselhoff, ex-The Young & The Restless), who was recruited by the Foundation for Law And Government (FLAG), which essentially was a variation on the Witness Protection Program in that Long was supposedly dead. Rechristened Michael Knight, he became an agent for FLAG, and given a supercar, the Knight Industries Two Thousand (KITT), which had an onboard computer that talked to its driver. William Daniels, who was starring on another NBC show, St. Elsewhere, around the same time, was the voice of KITT, and I'd imagine most people will remember him more for this gig or his later role on Boy Meets World than for his 60's series, Captain Nice.
Knight Rider lasted four seasons, but there've been two revivals since, the last coming 5 years ago. The 2008 model, with Val Kilmer taking over as the voice of KITT, was a failure, largely because it was airing on the wrong night.
Following is the open, and closing credits from a sample episode. Richard Basehart (ex-Voyage to the Bottom of the Sea), who played Wilton Knight in the pilot episode, is the narrator, but his vocals have been deleted.
Of course, we all know that David Hasselhoff followed up with Baywatch, which lasted almost three times as long as Knight Rider did, and his non-involvement in the 2008 revival may've played a part in that series' abrupt end.