Comedy Central has had a few hit shows, but aside from South Park, The Daily Show, and its spinoff, the Colbert Report, few have had the cultural impact, even done tongue in cheek, as Win Ben Stein's Money, which had a healthy run of six years on the network (1997-2003). Future talk show host Jimmy Kimmel was Stein's original partner in pandemonium, serving as MC most of the time during his three years on the show. Kimmel left in 2000 to co-host The Man Show before ABC signed him to be their late night talk host.
Howieandkeyshia uploaded this odd episode from June 1999 in which Stein, currently a pitchman for Visine eye drops, among other things, and Kimmel trade places for a day.
As you can tell from the above, GSN acquired the series, but I think Disney still owns the rights to the series, so it's languishing in the vaults.