After a star-making turn in "Beaches" opposite Bette Midler, Mayim Bialik landed her first TV gig in the title role of Blossom, which was often coupled with The Fresh Prince of Bel-Air at the front of NBC's Monday night lineup in the early 90's.
Blossom and her two brothers (Michael Stoyanov and Joey Lawrence) live with their father (Ted Wass, ex-Soap) after their mother leaves them. It is said that the part of Six (Jenna Von Oy) had originally been offered to another young actress, Melissa Joan Hart, who opted instead for Nickelodeon's Clarissa Explains it All. One can only imagine if Hart had taken the gig, as she & Bialik both became pop icons in the 90's.
When Blossom's mother did appear, she was played by singer Melissa Manchester. The revolving door ensemble also included Finola Hughes (General Hospital) and comedy legend Phyllis Diller as a paramedic.
Dr. John performs the title song, used during the first 4 seasons, but was dropped in the final season. Scope out how many wardrobe changes Blossom makes during the intro from season 3:
Today, after landing a Ph.D, Mayim Bialik has made a comeback as an actress, currently co-starring on CBS' The Big Bang Theory, and still looking as cute as ever, even with the big glasses.