In 1966, Stan Lee & Jack Kirby introduced Wakandan King T'Challa, the Black Panther, in the pages of Fantastic Four. The Panther would become an ally of Marvel's First Family, as well as becoming a member of the Avengers. 50 years later, the Panther was brought to life in "Captain America: Civil War", and his story continues in "Black Panther".
T'Challa (Chadwick Boseman) inherited the throne after his father, T'Chaka, was assassinated in "Civil War", and remains committed to preserving the secrets of Wakanda's advanced technology. However, his cousin, now going by the handle, Erik Stevens, aka Killmonger (Michael B. Jordan, "Fantastic Four", "Creed"), who has spent most of his formative years in the US, has returned home, seeking revenge after his father had been murdered years earlier. While here, Killmonger served in the military, developing his craft.
Added to the mix is Ulysses Klaue (Andy Serkis), better known to comics fans as Klaw, the master of sound. Instead of his signature sonic blaster, Klaue has a prosthetic arm with a retractable blaster mounted on it. It's not the same, and it's not as if Marvel/Disney suddenly decided to go el scrimpo.
What fans will see here is an amalgamation of other heroic icons such as Tarzan, Wonder Woman, and James Bond. You'd just have to see it to believe it and get the picture. Speaking of which, here's the trailer.
Of course, Stan gets his cameo in. It almost wouldn't be a Marvel Studios movie without him.